PP61 Plugging the Gap of Fetoscopy in Congenital Diaphragmatic Hernia Pregnancies: Value for Money?

Introduction Fetoscopic endoluminal tracheal occlusion (FETO) for congenital diaphragmatic hernia (CDH) fetuses increases the neonatal survival rate. However, FETO also number of preterm prelabour rupture membranes (PPROM) and deliveries (PTDs) as fetal membrane defects after fetoscopy do not spontaneously heal. To solve this issue, an advanced sealing plug is being developed. Through early-stage health economic modelling, we estimated potential value innovative in terms costs effects determined properties it to become cost-effective. Methods We applied modelling case performing singleton pregnant women whose fetus prenatally diagnosed with CDH. simulated a cohort using state-transition model over 45-year time horizon. In our best-case scenario analysis, compared current care strategy perfect strategy, which reduces PPROM PTDs by 100 percent, determine maximum quality-adjusted life years (QALYs) gained saved. Using threshold minimum percentage reduction be considered Model parameters’ impact on outcomes was investigated sensitivity analysis. Results Our indicated that would yield additional 1.94 QALYs at cost decrease EUR 2,554 per patient year. These values were strongly influenced very deliveries. Threshold analysis showed that, 500 plug, needs relative 1.83 percent (i.e., PPROM: 47.50 46.63 %, PTDs: 71.50 70.19 %) Conclusions model-based approach clear when context CDH fetuses, only small needed Its expected even higher used conditions suffering from more Continuation investment innovation’s research development seems provide money.